Pat the shrimp dry with paper towels to remove any excess moisture, then toss in Cajun seasoning until fully coated.
Lightly dredge the seasoned shrimp in all-purpose flour, shaking off any excess flour before cooking.
In a skillet over medium-high heat, add olive oil and allow it to heat up until shimmering but not smoking. Carefully place the shrimp in a single layer in the skillet.
Cook the shrimp for about 2–3 minutes on each side until they turn golden brown and are cooked through.
Prepare your creamy sauce by whisking together mayonnaise, hot sauce, smoked paprika, garlic powder, and lemon juice in a small bowl until well combined.
Arrange the crispy shrimp on a serving dish and drizzle generously with your creamy sauce before garnishing with fresh parsley or chives.