Place your chicken breasts in your crockpot insert. Cover them evenly with chili powder, cumin, paprika, garlic powder, and onion powder.
Pour one cup of salsa over the seasoned chicken breasts, ensuring they are fully coated. If desired, sprinkle lime juice over the top.
Add half a cup of low-sodium chicken broth or water into the crockpot insert to keep everything moist while cooking.
Cover the crockpot and cook on low for 4-6 hours or on high for 3-4 hours.
Once fully cooked, remove the chicken from the crockpot and shred it using two forks or a stand mixer.
Return the shredded chicken back into the crockpot insert to soak up all those delicious juices before serving.